Broad mesodermal and endodermal deletion of Nodal at postgastrulation stages results solely in left/right axial defects.

Abstract

Nodal signaling is a critical regulator of multiple aspects of early vertebrate development including asymmetry along the left/right (LR) axis. To study Nodal function occurring specifically in the postgastrulation embryo, we have used Cre/loxP based conditional mutagenesis. A floxed allele of Nodal was generated and shown to have wild-type function. This… (More)
DOI: 10.1002/dvdy.21665

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