Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals

  title={Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals},
  author={Johannes F. Scheid and Hugo Mouquet and Niklas Feldhahn and Michael S. Seaman and Klara Velinzon and John Pietzsch and Rene G. Ott and Robert M. Anthony and Henry A. Zebroski and Arlene M Hurley and Adhuna Phogat and Bimal K. Chakrabarti and Yuxing Li and Mark Connors and Florencia Pereyra and Bruce D. Walker and Hedda Wardemann and David Wing Ip Ho and Richard T. Wyatt and John R. Mascola and Jeffrey V Ravetch and Michel C. Nussenzweig},
Antibodies to conserved epitopes on the human immunodeficiency virus (HIV) surface protein gp140 can protect against infection in non-human primates, and some infected individuals show high titres of broadly neutralizing immunoglobulin (Ig)G antibodies in their serum. However, little is known about the specificity and activity of these antibodies. To characterize the memory antibody responses to HIV, we cloned 502 antibodies from HIV envelope-binding memory B cells from six HIV-infected… CONTINUE READING
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