Broad blocking of MDR efflux pumps by acetylshikonin and acetoxyisovalerylshikonin to generate hypersensitive phenotype of malignant carcinoma cells

@inproceedings{Mirzaei2018BroadBO,
  title={Broad blocking of MDR efflux pumps by acetylshikonin and acetoxyisovalerylshikonin to generate hypersensitive phenotype of malignant carcinoma cells},
  author={Seyed Abbas Mirzaei and Somayeh Reiisi and Parmida Ghiasi Tabari and Abolfazl Shekari and Fatemeh Aliakbari and Elaheh Azadfallah and Fatemeh Elahian},
  booktitle={Scientific Reports},
  year={2018}
}
Cytotoxic activities of acetylshikonin and acetoxyisovalerylshikonin alone and in combination with chemotherapeutic agents against parental and drug resistant cell lines were determined using the MTT assay. Effects of Shikonin derivatives on BCRP, MDR1 and MRP transcript and protein levels were relatively measured. Finally, accumulation and efflux kinetics were conducted. The results revealed cell- and concentration-dependency of the cell cytotoxicity. Acetylshikonin and… CONTINUE READING