Broad and persistent Gag-specific CD8+ T-cell responses are associated with viral control but rarely drive viral escape during primary HIV-1 infection.

@article{Radebe2015BroadAP,
  title={Broad and persistent Gag-specific CD8+ T-cell responses are associated with viral control but rarely drive viral escape during primary HIV-1 infection.},
  author={Mopo Radebe and Kamini Gounder and Mammekwa Mokgoro and Zaza M. Ndhlovu and Zenele Mncube and Lungile Mkhize and Mary van der Stok and Manjeetha Jaggernath and Bruce D. Walker and Thumbi Ndung'u},
  journal={AIDS},
  year={2015},
  volume={29 1},
  pages={23-33}
}
OBJECTIVE We characterized protein-specific CD8 T-cell immunodominance patterns during the first year of HIV-1 infection, and their impact on viral evolution and immune control. METHODS We analyzed CD8 T-cell responses to the full HIV-1 proteome during the first year of infection in 18 antiretroviral-naïve individuals with acute HIV-1 subtype C infection, all identified prior to seroconversion. Ex-vivo and cultured interferon-γ ELISPOT assays were performed and viruses from plasma were… CONTINUE READING
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