Broad T cell immunity to the LcrV virulence protein is induced by targeted delivery to DEC-205/CD205-positive mouse dendritic cells.

@article{Do2008BroadTC,
  title={Broad T cell immunity to the LcrV virulence protein is induced by targeted delivery to DEC-205/CD205-positive mouse dendritic cells.},
  author={Yoonkyung Do and Chae Gyu Park and Y. Kang and Sung Ho Park and R Lynch and Haekyung Lee and Bradford S Powell and Ralph Marvin Steinman},
  journal={European journal of immunology},
  year={2008},
  volume={38 1},
  pages={20-9}
}
There is a need for a more efficient vaccine against the bacterium Yersinia pestis, the agent of pneumonic plague. The F1-LcrV (F1-V) subunit vaccine in alhydrogel is known to induce humoral immunity. In this study, we utilized DC to investigate cellular immunity. We genetically engineered the LcrV virulence protein into the anti-DEC-205/CD205 mAb and thereby targeted the conjugated protein directly to mouse DEC-205(+) DC in situ. We observed antigen-specific CD4(+) T cell immunity measured by… CONTINUE READING

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