Broad Spectrum Resistance to ssDNA Viruses Associated with Transgene-Induced Gene Silencing in Cassava

@article{Chellappan2004BroadSR,
  title={Broad Spectrum Resistance to ssDNA Viruses Associated with Transgene-Induced Gene Silencing in Cassava},
  author={Padmanabhan Chellappan and Munyaradzi V. Masona and Ramachandran Vanitharani and Nigel J Taylor and Claude M. Fauquet},
  journal={Plant Molecular Biology},
  year={2004},
  volume={56},
  pages={601-611}
}
Geminiviruses are ssDNA viruses that infect a range of economically important crop species. We have developed a pathogen-derived transgenic approach to generate high levels of resistance against these pathogens in a susceptible cultivar of cassava (Manihot esculenta). Integration of the AC1 gene (which encodes the replication-associated protein) from African cassava mosaic virus imparted resistance against the homologous virus and provided strong cross-protection against two heterologous… CONTINUE READING

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