Broad-Spectrum Antiviral Activity of Virazole: 1-f8- D-Ribofuranosyl- 1,2,4-triazole- 3-carboxamide

@article{Sidwell1972BroadSpectrumAA,
  title={Broad-Spectrum Antiviral Activity of Virazole: 1-f8- D-Ribofuranosyl- 1,2,4-triazole- 3-carboxamide},
  author={Robert William Sidwell and John H. Huffman and G. P. Khare, Lois and B. Allen and J. T. Witkowski, Roland and Karen Robins},
  journal={Science},
  year={1972},
  volume={177},
  pages={705 - 706}
}
Virazole is a synthetic nucleoside active in tissue culture against at least 16 DNA and RNA viruses. Applied topically, it inhibits herpetic keratitis in rabbits and tail lesions induced by herpes, vaccinia, and vesicular stomatitis viruses in mice. Injected intraperitoneally into mice, it inhibits splenomegaly and hepatomegaly induced by Friend leukemia virus and respiratory infections caused by influenza AO, A2, and B viruses and parainfluenza 1 virus. infections is also effective. 
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936 Citations
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936 Citations

EFFICACY OF RIBAVIRIN AGAINST INFLUENZA VIRUS IN TISSUE CULTURE AND IN MICE
TLDR
Efficacy against influenza virus type A, A2, and B infections in mice has been confirmed by us, and the results of experiments that bear on the effects of the drug on the infectious process are presented.
Inhibition of Respiratory Syncytial Virus Replication in vitro by a Pyrazole Dicarboxamide Analogue of Ribavirin
1-β-D-Ribofuranosylpyrazole-3,4-dicarboxamide (GR-92938X) was found to be an inhibitor of respiratory syncytial virus in vitro, with a potency equivalent to that of ribavirin. The compound was more…
Suppression by 1-β-d-Ribofuranosyl-1,2,4-Triazole-3-Carboxamide (Virazole, ICN 1229) of Influenza Virus-Induced Infections in Mice
1-β-d-Ribofuranosyl-1,2,4-triazole-3-carboxamide (Virazole) was found to possess significant antiviral activity against aerosol-induced or intranasally induced influenza A0, A2, and B virus…
An evaluation of a new antiviral agent "virazole" against influenza virus infections.
A new antiviral agent Virazole (1-B-D-Ribofuranosyl-1, 2, 4-triazole-3-carboxamide) was tested for its antiviral effect against influenza A virus infections both in vitro and in vivo. Withoutt any…
Broad-spectrum antiviral activity of the carbocyclic analog of 3-deazaadenosine.
Effect of Ribavirin on Murine Cytomegalovirus Infection
Ribavirin (1-β-d-ribofuranosyl-1,2,4-triazole-3-carboxamide), a new synthetic nucleoside, inhibited murine cytomegalovirus in cell culture. This was shown by the inhibition of viral cytopathic effect…
MINIREVIEW Biochemistry and Clinical Applications of Ribavirin
TLDR
The current data on ribavirin as to chemical structure, possible mode(s) of action, metabolic disposition, and clinical use as an antiviral agent are summarized.
Biochemistry and clinical applications of ribavirin.
TLDR
The current data on ribavirin as to chemical structure, possible mode(s) of action, metabolic disposition, and clinical use as an antiviral agent are summarized.
Effect of 1-β-d-Ribofuranosyl-1,2,4-Triazole-3-Carboxamide (Virazole, ICN 1229) on Herpes and Vaccinia Keratitis and Encephalitis in Laboratory Animals
Topical application of 1-β-d-ribofuranosyl-1,2,4-triazole-3-carboxamide (Virazole) significantly inhibited the development of herpetic keratitis in the eyes of rabbits, as determined by both…
Efficacy of 1-β-d-Ribofuranosyl-1,2,4-Triazole-3-carboxamide Against Influenza Virus Infections in Mice
TLDR
Ribavirin appears to exert its protective effects against influenza infections by inhibiting virus growth, thereby preventing virus titers from reaching levels that result in massive lung tissue destruction and death of the mice.
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The virus rating (VR) method was originally described by
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    The antiviral activity of ten compounds, expressed in VR, was determined in microplate tissue cultures (2) and can be compared with that of Virazole
      The airborne infection apparatus used was obtained from Tri-R Co
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      • 1952
      In this method, a VR of -1.0 indicates marked antiviral activity, a VR of 0.5 to 0.9 indicates moderate activity, and a VR of 0.1 to 0.4 suggests only slight antiviral activity
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