Broad-Spectrum Antiviral Activity of Virazole: 1-f8- D-Ribofuranosyl- 1,2,4-triazole- 3-carboxamide

@article{Sidwell1972BroadSpectrumAA,
  title={Broad-Spectrum Antiviral Activity of Virazole: 1-f8- D-Ribofuranosyl- 1,2,4-triazole- 3-carboxamide},
  author={Robert William Sidwell and John H. Huffman and G. P. Khare, Lois and B. Allen and J. T. Witkowski, Roland and Karen Robins},
  journal={Science},
  year={1972},
  volume={177},
  pages={705 - 706}
}
Virazole is a synthetic nucleoside active in tissue culture against at least 16 DNA and RNA viruses. Applied topically, it inhibits herpetic keratitis in rabbits and tail lesions induced by herpes, vaccinia, and vesicular stomatitis viruses in mice. Injected intraperitoneally into mice, it inhibits splenomegaly and hepatomegaly induced by Friend leukemia virus and respiratory infections caused by influenza AO, A2, and B viruses and parainfluenza 1 virus. infections is also effective. 
View on AAAS
ncbi.nlm.nih.gov
942 Citations
Highly Influential Citations
14
Background Citations
226
Methods Citations
17
Results Citations
5

942 Citations

EFFICACY OF RIBAVIRIN AGAINST INFLUENZA VIRUS IN TISSUE CULTURE AND IN MICE

TLDR
Efficacy against influenza virus type A, A2, and B infections in mice has been confirmed by us, and the results of experiments that bear on the effects of the drug on the infectious process are presented.

Molecular mechanisms of action of ribavirin.

TLDR
The major mechanisms of action of ribavirin are described, reported to slow the development of AIDS in HIV-infected patients and to be able to treat infections due to HIV.

Inhibition of Respiratory Syncytial Virus Replication in vitro by a Pyrazole Dicarboxamide Analogue of Ribavirin

1-β-D-Ribofuranosylpyrazole-3,4-dicarboxamide (GR-92938X) was found to be an inhibitor of respiratory syncytial virus in vitro, with a potency equivalent to that of ribavirin. The compound was more…

Suppression by 1-β-d-Ribofuranosyl-1,2,4-Triazole-3-Carboxamide (Virazole, ICN 1229) of Influenza Virus-Induced Infections in Mice

1-β-d-Ribofuranosyl-1,2,4-triazole-3-carboxamide (Virazole) was found to possess significant antiviral activity against aerosol-induced or intranasally induced influenza A0, A2, and B virus…

An evaluation of a new antiviral agent "virazole" against influenza virus infections.

A new antiviral agent Virazole (1-B-D-Ribofuranosyl-1, 2, 4-triazole-3-carboxamide) was tested for its antiviral effect against influenza A virus infections both in vitro and in vivo. Withoutt any…

Broad-spectrum antiviral activity of the carbocyclic analog of 3-deazaadenosine.

Effect of Ribavirin on Murine Cytomegalovirus Infection

Ribavirin (1-β-d-ribofuranosyl-1,2,4-triazole-3-carboxamide), a new synthetic nucleoside, inhibited murine cytomegalovirus in cell culture. This was shown by the inhibition of viral cytopathic effect…

MINIREVIEW Biochemistry and Clinical Applications of Ribavirin

TLDR
The current data on ribavirin as to chemical structure, possible mode(s) of action, metabolic disposition, and clinical use as an antiviral agent are summarized.

Biochemistry and clinical applications of ribavirin.

TLDR
The current data on ribavirin as to chemical structure, possible mode(s) of action, metabolic disposition, and clinical use as an antiviral agent are summarized.

Effect of 1-β-d-Ribofuranosyl-1,2,4-Triazole-3-Carboxamide (Virazole, ICN 1229) on Herpes and Vaccinia Keratitis and Encephalitis in Laboratory Animals

Topical application of 1-β-d-ribofuranosyl-1,2,4-triazole-3-carboxamide (Virazole) significantly inhibited the development of herpetic keratitis in the eyes of rabbits, as determined by both…
...

References

SHOWING 1-9 OF 9 REFERENCES

SEARCHING FOR ANTIVIRAL MATERIALS FROM MICROBIAL FERMENTATIONS

TLDR
This report is an account of a joint endeavor at Parke-Davis and Southern Research Institute (Birmingham, Ala.) to obtain antiviral materials from microbial fermentations, beginning with culture isolation and ending with preparation of chemical concentrates.

Use of disposable micro tissue culture plates for antiviral and interferon induction studies.

TLDR
A reproducible test system requiring small amounts of test compound was developed for evaluating antiviral and interferon-inducing activity and known active compounds evaluated in this microplate system had activity similar to that seen in macro in vitro systems.

An Apparatus for Airborne Infection of Mice

  • G. Middlebrook
  • Biology
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1952
TLDR
A safe and relatively inexpensive laboratory apparatus for the experimental airborne infection of as many as 100 mice at a time and has been used for the production of murine pulmonary tuberculosis with tubercle bacilli cultivated in Tween-albumin liquid medium.

On a Test of Whether one of Two Random Variables is Stochastically Larger than the Other

The virus rating (VR) method was originally described by

    The virus rating (VR) method

    • [Ann. N.Y. Acad. Sci
    • 1963

    The antiviral activity of ten compounds, expressed in VR, was determined in microplate tissue cultures (2) and can be compared with that of Virazole

      The airborne infection apparatus used was obtained from Tri-R Co

      • Proc. Soc. Exp. BioL Med
      • 1952

      In this method, a VR of -1.0 indicates marked antiviral activity, a VR of 0.5 to 0.9 indicates moderate activity, and a VR of 0.1 to 0.4 suggests only slight antiviral activity

      • 1965