Broad-Spectrum Antiviral Activity of Virazole: 1-f8- D-Ribofuranosyl- 1,2,4-triazole- 3-carboxamide

@article{Sidwell1972BroadSpectrumAA,
  title={Broad-Spectrum Antiviral Activity of Virazole: 1-f8- D-Ribofuranosyl- 1,2,4-triazole- 3-carboxamide},
  author={Robert William Sidwell and John H. Huffman and G. P. Khare, Lois and B. Allen and J. T. Witkowski, Roland and Karen T. Robins},
  journal={Science},
  year={1972},
  volume={177},
  pages={705 - 706}
}
Virazole is a synthetic nucleoside active in tissue culture against at least 16 DNA and RNA viruses. Applied topically, it inhibits herpetic keratitis in rabbits and tail lesions induced by herpes, vaccinia, and vesicular stomatitis viruses in mice. Injected intraperitoneally into mice, it inhibits splenomegaly and hepatomegaly induced by Friend leukemia virus and respiratory infections caused by influenza AO, A2, and B viruses and parainfluenza 1 virus. infections is also effective. 
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EFFICACY OF RIBAVIRIN AGAINST INFLUENZA VIRUS IN TISSUE CULTURE AND IN MICE
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Efficacy against influenza virus type A, A2, and B infections in mice has been confirmed by us, and the results of experiments that bear on the effects of the drug on the infectious process are presented. Expand
Molecular mechanisms of action of ribavirin.
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The major mechanisms of action of ribavirin are described, reported to slow the development of AIDS in HIV-infected patients and to be able to treat infections due to HIV. Expand
Inhibition of Respiratory Syncytial Virus Replication in vitro by a Pyrazole Dicarboxamide Analogue of Ribavirin
1-β-D-Ribofuranosylpyrazole-3,4-dicarboxamide (GR-92938X) was found to be an inhibitor of respiratory syncytial virus in vitro, with a potency equivalent to that of ribavirin. The compound was more… Expand
Suppression by 1-β-d-Ribofuranosyl-1,2,4-Triazole-3-Carboxamide (Virazole, ICN 1229) of Influenza Virus-Induced Infections in Mice
1-β-d-Ribofuranosyl-1,2,4-triazole-3-carboxamide (Virazole) was found to possess significant antiviral activity against aerosol-induced or intranasally induced influenza A0, A2, and B virus… Expand
An evaluation of a new antiviral agent "virazole" against influenza virus infections.
A new antiviral agent Virazole (1-B-D-Ribofuranosyl-1, 2, 4-triazole-3-carboxamide) was tested for its antiviral effect against influenza A virus infections both in vitro and in vivo. Withoutt any… Expand
Broad-spectrum antiviral activity of the carbocyclic analog of 3-deazaadenosine.
TLDR
In its activity against vesicular stomatitis virus, parainfluenza virus, measles and reo virus, C-c3 Ado proved about 100 times more potent than other established broad-spectrum antiviraL agents such as ribavirin (virazole) and (S)-DHPA ((S)-9-(2,3-dihydroxypropyl)adenine). Expand
Effect of Ribavirin on Murine Cytomegalovirus Infection
Ribavirin (1-β-d-ribofuranosyl-1,2,4-triazole-3-carboxamide), a new synthetic nucleoside, inhibited murine cytomegalovirus in cell culture. This was shown by the inhibition of viral cytopathic effect… Expand
Biochemistry and clinical applications of ribavirin.
TLDR
The current data on ribavirin as to chemical structure, possible mode(s) of action, metabolic disposition, and clinical use as an antiviral agent are summarized. Expand
Effect of 1-β-d-Ribofuranosyl-1,2,4-Triazole-3-Carboxamide (Virazole, ICN 1229) on Herpes and Vaccinia Keratitis and Encephalitis in Laboratory Animals
Topical application of 1-β-d-ribofuranosyl-1,2,4-triazole-3-carboxamide (Virazole) significantly inhibited the development of herpetic keratitis in the eyes of rabbits, as determined by both… Expand
5′-Nor Carbocyclic Ribavirin
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Compound 4 was evaluated against the following viruses and no activity was found nor was there any cytotoxicity to the viral host cells. Expand
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References

SHOWING 1-9 OF 9 REFERENCES
SEARCHING FOR ANTIVIRAL MATERIALS FROM MICROBIAL FERMENTATIONS
TLDR
This report is an account of a joint endeavor at Parke-Davis and Southern Research Institute (Birmingham, Ala.) to obtain antiviral materials from microbial fermentations, beginning with culture isolation and ending with preparation of chemical concentrates. Expand
Use of disposable micro tissue culture plates for antiviral and interferon induction studies.
TLDR
A reproducible test system requiring small amounts of test compound was developed for evaluating antiviral and interferon-inducing activity and known active compounds evaluated in this microplate system had activity similar to that seen in macro in vitro systems. Expand
An Apparatus for Airborne Infection of Mice
  • G. Middlebrook
  • Biology, Medicine
  • Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1952
TLDR
A safe and relatively inexpensive laboratory apparatus for the experimental airborne infection of as many as 100 mice at a time and has been used for the production of murine pulmonary tuberculosis with tubercle bacilli cultivated in Tween-albumin liquid medium. Expand
In this method, a VR of -1.0 indicates marked antiviral activity, a VR of 0.5 to 0.9 indicates moderate activity, and a VR of 0.1 to 0.4 suggests only slight antiviral activity
  • 1965
The virus rating (VR) method
  • [Ann. N.Y. Acad. Sci
  • 1963
The airborne infection apparatus used was obtained from Tri-R Co
  • Proc. Soc. Exp. BioL Med
  • 1952
On a Test of Whether one of Two Random Variables is Stochastically Larger than the Other
The antiviral activity of ten compounds, expressed in VR, was determined in microplate tissue cultures (2) and can be compared with that of Virazole
    The virus rating (VR) method was originally described by