Broad Inhibition Sharpens Orientation Selectivity by Expanding Input Dynamic Range in Mouse Simple Cells

@article{Liu2011BroadIS,
  title={Broad Inhibition Sharpens Orientation Selectivity by Expanding Input Dynamic Range in Mouse Simple Cells},
  author={Baohua Liu and Ya-tang Li and Wen-pei Ma and Chen-jie Pan and Li Zhang and Huizhong Whit Tao},
  journal={Neuron},
  year={2011},
  volume={71},
  pages={542-554}
}
Orientation selectivity (OS) is an emergent property in the primary visual cortex (V1). How OS arises from synaptic circuits remains unsolved. Here, in vivo whole-cell recordings in the mouse V1 revealed that simple cells received broadly tuned excitation and even more broadly tuned inhibition. Excitation and inhibition shared a similar orientation preference and temporally overlapped substantially. Neuron modeling and dynamic-clamp recording further revealed that excitatory inputs alone would… CONTINUE READING