Broad Conditions Favor the Evolution of Phase-Variable Loci

  title={Broad Conditions Favor the Evolution of Phase-Variable Loci},
  author={M. Elizabeth Palmer and Marc Lipsitch and E . Richard Moxon and Christopher D Bayliss},
UNLABELLED Simple sequence repeat (SSR) tracts produce stochastic on-off switching, or phase variation, in the expression of a panoply of surface molecules in many bacterial commensals and pathogens. A change to the number of repeats in a tract may alter the phase of the translational reading frame, which toggles the on-off state of the switch. Here, we construct an in silico SSR locus with mutational dynamics calibrated to those of the Haemophilus influenzae mod locus. We simulate its… CONTINUE READING
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