• Biology, Medicine
  • Published in Development 2002

Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth.

@article{Wang2002Brn3bBrn3cDK,
  title={Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth.},
  author={Steven Wen Wang and Xiuqian Mu and William J. Bowers and D. Kim and Daniel J Plas and Michael C. Crair and Howard J. Federoff and Lin Gan and William H. Klein},
  journal={Development},
  year={2002},
  volume={129 2},
  pages={
          467-77
        }
}
In mice, Brn3 POU domain transcription factors play essential roles in the differentiation and survival of projection neurons within the retina, inner ear, dorsal root and trigeminal ganglia. During retinal ganglion cell differentiation, Brn3b is expressed first, followed by Brn3a and Brn3c. Targeted deletion of Brn3b, but not Brn3a or Brn3c, leads to a loss of most retinal ganglion cells before birth. However, as a few retinal ganglion cells are still present in Brn3b(-/-) mice, Brn3a and… CONTINUE READING

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