Brn-2 expression controls melanoma proliferation and is directly regulated by beta-catenin.

@article{Goodall2004Brn2EC,
  title={Brn-2 expression controls melanoma proliferation and is directly regulated by beta-catenin.},
  author={Jane Goodall and Silvia Martinozzi and Timothy J Dexter and Delphine Champeval and Suzanne Carreira and Lionel Larue and C. R. Goding},
  journal={Molecular and cellular biology},
  year={2004},
  volume={24 7},
  pages={2915-22}
}
Constitutive activation of the Wnt/beta-catenin signaling pathway is a notable feature of a large minority of cases of malignant melanoma, an aggressive and increasingly common cancer. The identification of target genes downstream from this pathway is therefore crucial to our understanding of the disease. The POU domain transcription factor Brn-2 has been implicated in control of proliferation and melanoma survival, and its expression is strongly upregulated in melanoma. We show here that in… CONTINUE READING