Brivaracetam augments short-term depression and slows vesicle recycling.

  title={Brivaracetam augments short-term depression and slows vesicle recycling.},
  author={Xiaofeng Yang and Joseph Bognar and Tianyu He and Mouhari Mohammed and Isabelle Niespodziany and Christian Wolff and Manuel Q. Esguerra and Steven M. Rothman and Janet M. Dubinsky},
  volume={56 12},
OBJECTIVE Brivaracetam (BRV) decreases seizure activity in a number of epilepsy models and binds to the synaptic vesicle glycoprotein 2A (SV2A) with a higher affinity than the antiepileptic drug levetiracetam (LEV). Experiments were performed to determine if BRV acted similarly to LEV to induce or augment short-term depression (STD) under high-frequency neuronal stimulation and slow synaptic vesicle recycling. METHODS Electrophysiologic field excitatory postsynaptic potential (fEPSP… CONTINUE READING
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