Brinker is a sequence-specific transcriptional repressor in the Drosophila embryo.

@article{Zhang2001BrinkerIA,
  title={Brinker is a sequence-specific transcriptional repressor in the Drosophila embryo.},
  author={H L Zhang and Michael Levine and Hilary L. Ashe},
  journal={Genes & development},
  year={2001},
  volume={15 3},
  pages={261-6}
}
A Dpp activity gradient specifies multiple thresholds of gene expression in the dorsal ectoderm of the early embryo. Some of these thresholds depend on a putative repressor, Brinker, which is expressed in the neurogenic ectoderm in response to the maternal Dorsal gradient and Dpp signaling. Here we show that Brinker is a sequence-specific transcriptional repressor. It binds the consensus sequence, TGGCGc/tc/t, and interacts with the Groucho corepressor through a conserved sequence motif, FKPY… CONTINUE READING