Bringing together models from bottom-up and top-down approaches: an application for growth of Escherichia coli on different carbohydrates.

Modeling in systems biology follows two lines: a data driven top-down approach that integrates experimental data from various "omics" technologies and a model based bottom-up approach where the model structure is given and kinetic parameters are chosen in such a way that an experimental observation can be reproduced quantitatively or qualitatively… (More)