Bringing next-generation therapeutics to the clinic through synthetic biology.

Abstract

Recent advances in synthetic biology have created genetic tools with the potential to enhance the specificity, dynamic control, efficacy, and safety of medical treatments. Interfacing these genetic devices with human patients may thus bring about more efficient treatments or entirely new solutions to presently intractable maladies. Here we review engineered circuits with clinical potential and discuss their design, implementation, and validation.

DOI: 10.1016/j.cbpa.2012.04.009

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Cite this paper

@article{Bugaj2012BringingNT, title={Bringing next-generation therapeutics to the clinic through synthetic biology.}, author={Lukasz J. Bugaj and David V. Schaffer}, journal={Current opinion in chemical biology}, year={2012}, volume={16 3-4}, pages={355-61} }