Bringing Warburg to lymphocytes

@article{Medzhitov2015BringingWT,
  title={Bringing Warburg to lymphocytes},
  author={Ruslan Medzhitov},
  journal={Nature Reviews Immunology},
  year={2015},
  volume={15},
  pages={598-598}
}
  • R. Medzhitov
  • Published 1 October 2015
  • Biology
  • Nature Reviews Immunology
Ruslan Medzhitov describes a 2002 paper by Craig Thompson and colleagues that brought the concept of Warburg metabolism to lymphocytes. 
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7 Citations
Background Citations
6

7 Citations

Lymphocyte Fate and Metabolism: A Clonal Balancing Act.

Contribution of ROS and metabolic status to neonatal and adult CD8+ T cell activation

TLDR
A logical model connecting metabolism and ROS with T cell signaling is constructed, indicating the interplay between antigen recognition, ROS and metabolic status in T cell responses and can serve to analyze the impact of metabolic shift during cancer.

Oleanolic Acid Inhibits High Salt-Induced Exaggeration of Warburg-like Metabolism in Breast Cancer Cells

TLDR
Data indicate that OA efficiently reverses the enhanced Warburg-like metabolism induced by high salt-mediated osmotic stress along with potential application of OA in anti-cancer therapy.

Monitoring Immune Activation with Whole-Body

TLDR
The bowel FDG uptake of uninfected animals was heterogeneous and reached levels as high as those seen in the bowel or the clusters of lymph nodes or the spleen of high viremic Siv-infected animals, suggesting that factors beyond SIV-induced immune activation dominate the gut FDg uptake.

Landscape of T Cells Transcriptional and Metabolic Modules During HIV Infection Based on Weighted Gene Co-expression Network Analysis

TLDR
The core gene expression modules and different pathways activated in CD4+ and CD8+ T cells, along with changes in their metabolic pathways during HIV infection progression, can provide an overall resource for establishing biomarkers to facilitate early diagnosis and potential guidance for new targeted therapeutic strategies.

Saturation of the mitochondrial NADH shuttles drives aerobic glycolysis in proliferating cells.

Transcriptomic meta-analysis identifies gene expression characteristics in various samples of HIV-infected patients with nonprogressive disease

TLDR
It is determined that nonprogressors have reduced expression of important interferon-stimulated genes (ISGs), CD38, lymphocyte activation gene 3 (LAG-3) in whole blood, CD4+ and CD8+ T cells.

References

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The CD28 signaling pathway regulates glucose metabolism.

Oleanolic Acid Inhibits High Salt-Induced Exaggeration of Warburg-like Metabolism in Breast Cancer Cells

TLDR
Data indicate that OA efficiently reverses the enhanced Warburg-like metabolism induced by high salt-mediated osmotic stress along with potential application of OA in anti-cancer therapy.