Brine shrimp: a convenient general bioassay for active plant constituents.

  title={Brine shrimp: a convenient general bioassay for active plant constituents.},
  author={Beverly Meyer and N R Ferrigni and John L Putnam and L B Jacobsen and David E. Nichols and Jerry McLaughlin},
  journal={Planta medica},
  volume={45 5},
A method, utilizing brine shrimp (Artemia salina Leach), is proposed as a simple bioassay for natural product research. The procedure determines LC (50) values in microg/ml of active compounds and extracts in the brine medium. Activities of a broad range of known active compounds are manifested as toxicity to the shrimp. Screening results with seed extracts of 41 species of Euphorbiaceae were compared with 9KB and 9PS cytotoxicities. The method is rapid, reliable, inexpensive, and convenient as… CONTINUE READING
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