Brimonidine promotes axon growth after optic nerve injury through Erk phosphorylation

@inproceedings{Fujita2013BrimonidinePA,
  title={Brimonidine promotes axon growth after optic nerve injury through Erk phosphorylation},
  author={Yu Fujita and Akitsugu Sato and Toshihide Yamashita},
  booktitle={Cell Death and Disease},
  year={2013}
}
It is well known that axons of the adult mammalian central nervous system have a very limited ability to regenerate after injury. Therefore, the neurodegenerative process of glaucoma results in irreversible functional deficits, such as blindness. Brimonidine (BMD) is an alpha2-adrenergic receptor agonist that is used commonly to lower intraocular pressure in glaucoma. Although it has been suggested that BMD has neuroprotective effects, the underlying mechanism remains unknown. In this study, we… CONTINUE READING

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