Brimonidine prevents neurodegeneration in a mouse model of normal tension glaucoma

  title={Brimonidine prevents neurodegeneration in a mouse model of normal tension glaucoma},
  author={Kentaro Semba and Kazuhiko Namekata and Atsuko Kimura and Chikako Harada and Yoshinori Mitamura and Tatsuya Harada},
  booktitle={Cell Death and Disease},
Glaucoma is one of the leading causes of irreversible blindness that is characterized by progressive degeneration of optic nerves and retinal ganglion cells (RGCs). In the mammalian retina, excitatory amino-acid carrier 1 (EAAC1) is expressed in neural cells, including RGCs, and the loss of EAAC1 leads to RGC degeneration without elevated intraocular pressure (IOP). Brimonidine (BMD) is an α2-adrenergic receptor agonist and it is commonly used in a form of eye drops to lower IOP in glaucoma… CONTINUE READING


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