Brimonidine and inhibition of nitrite production in isolated porcine ciliary processes.

@article{Liu2001BrimonidineAI,
  title={Brimonidine and inhibition of nitrite production in isolated porcine ciliary processes.},
  author={R Liu and Josef Flammer and Ivan O. Haefliger},
  journal={Klinische Monatsblatter fur Augenheilkunde},
  year={2001},
  volume={218 5},
  pages={
          348-50
        }
}
PURPOSE To investigate whether the alpha 2-adrenoreceptor agonist brimonidine (a drug that decreases intraocular pressure in part by reducing aqueous humor production) can inhibit the production of nitrite induced by forskolin in isolated porcine ciliary processes. METHODS Nitrite (a metabolite of nitric oxide) was measured (Griess reaction) before and two hours after exposure to the adenylcyclase activator forskolin (0.1 microM) in the presence or in the absence of the brimonidine (10 microM… Expand
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The discovery of the Flammer syndrome: a historical and personal perspective
TLDR
Clinical and basic research that led to the description of Flammer syndrome is described, which seemed to increase the risk for certain eye diseases, particularly in younger patients and also for certain drugs and increased retinal venous pressure. Expand