Brimonidine Protects Auditory Hair Cells from in vitro-Induced Toxicity of Gentamicin

  title={Brimonidine Protects Auditory Hair Cells from in vitro-Induced Toxicity of Gentamicin},
  author={Maurizio Cortada and Soledad Levano and Daniel J Bodmer},
  journal={Audiology and Neurotology},
  pages={125 - 134}
Brimonidine, an alpha-2 adrenergic receptor (α2-AR) agonist, has neuroprotective effects in the visual system and in spiral ganglion neurons. Auditory hair cells (HCs) express all 3 α2-AR subtypes, but their roles in HCs remain unknown. This study investigated the effects of brimonidine on auditory HCs that were also exposed to gentamicin, which is toxic to HCs. Organ of Corti explants were exposed to gentamicin in the presence or absence of brimonidine, and the α2-AR protein expression levels… Expand
2 Citations
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