Brilliant blue G selectively blocks ATP-gated rat P2X(7) receptors.

  title={Brilliant blue G selectively blocks ATP-gated rat P2X(7) receptors.},
  author={L H Jiang and Amanda B Mackenzie and R Alan North and Annmarie Surprenant},
  journal={Molecular pharmacology},
  volume={58 1},
There are few antagonists selective for subtypes of the several P2X receptors, but these are needed to identify the receptors expressed on native cells and tissues. In particular, P2X(4) and P2X(7) receptor subunits are colocalized on immune, epithelial, and exocrine gland cells, but both are relatively insensitive to suramin and pyridoxal-5-phosphate-6-azo-2',4'-disulfonic acid derivative. In this article, we show that Coomassie Brilliant Blue G selectively inhibits P2X(7) receptors with… CONTINUE READING
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Pharmacology of P 2 X receptors

  • RA North, A Surprenant
  • Annu Rev Pharmacol Toxicol
  • 2000
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