Bright and dark sides of nitric oxide in ischemic brain injury

  title={Bright and dark sides of nitric oxide in ischemic brain injury},
  author={C Iadecola},
  journal={Trends in Neurosciences},
There is increasing evidence that nitric oxide (NO), a free radical that can act both as a signaling molecule and a neurotoxin, is involved in the mechanisms of cerebral ischemia. Although early investigations yielded conflicting results, the introduction of more-selective pharmacological tools and the use of molecular approaches for deletion of genes encoding for NO synthase have provided a better understanding of the role of NO in the mechanisms of ischemic brain damage. The evidence reviewed… CONTINUE READING
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