Brief report: Lack of response in an autistic population to a low dose clinical trial of pyridoxine plus magnesium

@article{Tolbert1993BriefRL,
  title={Brief report: Lack of response in an autistic population to a low dose clinical trial of pyridoxine plus magnesium},
  author={Lelland C. Tolbert and Terry Haigler and M M Waits and Travis Dennis},
  journal={Journal of Autism and Developmental Disorders},
  year={1993},
  volume={23},
  pages={193-199}
}
The initial studies of the efficacy of megavitamin therapy in general, and pyridoxine in particular, in an autistic population were conducted by Rimland (1973; Rimland, Caltaway, & Dreyfuss, 1978). Subsequent to Rimland's positive reports, a group of investigators in France evaluated pyridoxine or pyridoxine plus magnesium interventions in autistic subjects in a series of reports employing both open and double-blind trials with both "clinical impression" and objectively scored behavioral… Expand
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References

SHOWING 1-10 OF 17 REFERENCES
Clinical and biological effects of high doses of vitamin B6 and magnesium on autistic children.
TLDR
Biochemical data analysis revealed that a significant decrease in urinary homovanillic acid (HVA) levels was observed during B6-Mg administration, and middle latency evoked potentials exhibited a significant increase of amplitude during treatment. Expand
Effects of pyridoxine and magnesium on autistic symptoms—Initial observations
TLDR
In an open trial, a heterogeneous group of 44 children with autistic symptoms were treated with large doses of vitamin B6 and magnesium and the responses to the open trial were confirmed. Expand
Vitamin B6 Safety Issues
TLDR
Preclinical and clinical data on pyridoxine neurotoxicity are updated to determine whether a more quantitative estimate of risk can be derived based on available data, and recent human and animal data showing lack of teratogenicity for pyrIDoxine are summarized. Expand
The effect of high doses of vitamin B6 on autistic children: a double-blind crossover study.
The authors used data from an earlier nonblind study to identify 16 autistic-type child outpatients who had apparently improved when given vitamin B6 (pyridoxine). In a double-blind study eachExpand
Vitamin B6, magnesium, and combined B6-Mg: Therapeutic effects in childhood autism
TLDR
The behavioral improvement observed with the combination vitamin B6-magnesium was associated with significant modifications of both biochemical and electrophysiological parameters: the urinary HVA excretion decreased, and EP amplitude and morphology seemed to be normalized. Expand
Effects of vitamin B6 on averaged evoked potentials in infantile autism.
TLDR
During treatment of the autistic children with B6, an increase of amplitude of middle-latency evoked potentials and a decrease of urinary homovanillic acid were found and the reverse was noted in the normal subjects. Expand
Safety of pyridoxine--a review of human and animal studies.
TLDR
Doses less than 500 mg/day appear to be safe on the basis of literature reports where the compound was administered for periods ranging from 6 months to 6 years. Expand
Carpal tunnel syndrome and vitamin B6.
TLDR
It is felt that regulated use of vitamin B6 may be helpful in treating many cases of carpal tunnel syndrome, and the findings were not the result of a controlled scientific study. Expand
Pyridoxine Dependency Seizures
  • R. Pettit
  • Medicine
  • Journal of child neurology
  • 1987
TLDR
The amount of pyridoxine required to control seizures is variable and may exceed 100 mg per day and the electroencephalogram (EEG) may not change significantly during the initiation of therapy. Expand
ELECTROPHYSIOLOGICAL EFFECTS OF FENFLURAMINE OR COMBINED VITAMIN B6 AND MAGNESIUM ON CHILDREN WITH AUTISTIC BEHAVIOUR
The authors compared the effects of fenfluramine or combined vitamin B6 and magnesium treatment on the evoked potential conditioning of 12 children whose autistic behaviour had improved clinicallyExpand
...
1
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