Brief neuroleptic discontinuation and clinical symptoms in Kraepelinian and non-Kraepelinian chronic schizophrenic patients

@article{Harvey1991BriefND,
  title={Brief neuroleptic discontinuation and clinical symptoms in Kraepelinian and non-Kraepelinian chronic schizophrenic patients},
  author={Philip D. Harvey and Katherine M. Putnam and Michael Davidson and Ren{\'e} S. Kahn and Kenneth L. Davis},
  journal={Psychiatry Research},
  year={1991},
  volume={38},
  pages={285-292}
}
Neuroleptic medication was abruptly discontinued in 24 male chronic schizophrenic patients who were subdivided on the basis of their history of illness into Kraepelinian (n = 8) and non-Kraepelinian (n = 16) subgroups. These patients were kept drug free for 6 weeks and then returned to treatment with haloperidol, 20 mg/day. Half of the non-Kraepelinian patients developed exacerbations of their symptoms, which quickly resolved when they were returned to medication, while none of the Kraepelinian… CONTINUE READING
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