Brief exposure to high-dose transforming growth factor-beta1 enhances periosteal chondrogenesis in vitro: a preliminary report.

@article{Miura2002BriefET,
  title={Brief exposure to high-dose transforming growth factor-beta1 enhances periosteal chondrogenesis in vitro: a preliminary report.},
  author={Yasushi Miura and Javad Parvizi and James S. Fitzsimmons and Shawn W O'driscoll},
  journal={The Journal of bone and joint surgery. American volume},
  year={2002},
  volume={84-A 5},
  pages={793-9}
}
BACKGROUND Articular cartilage has limited potential for repair. There have been various attempts aimed at improving the repair process in articular cartilage. Transforming growth factor-beta1 (TGF-beta1) has a stimulatory effect on chondrogenesis in periosteal explants. The purpose of the present study was to determine the effect of brief exposures (i.e., thirty and sixty minutes) of high concentrations of TGF-beta1 on periosteal chondrogenesis. METHODS Five hundred and seventy-three… CONTINUE READING

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