Brief episode of STZ-induced hyperglycemia produces cardiac abnormalities in rats fed a diet rich in n-6 PUFA.

@article{Ghosh2004BriefEO,
  title={Brief episode of STZ-induced hyperglycemia produces cardiac abnormalities in rats fed a diet rich in n-6 PUFA.},
  author={Sanjoy Ghosh and Dake Qi and Ding An and Thomas Pulinilkunnil and Ashraf Abrahani and Kuo-Hsing Kuo and Richard B. Wambolt and Michael F. Allard and Sheila M. Innis and Brian Rodrigues},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2004},
  volume={287 6},
  pages={
          H2518-27
        }
}
Diabetic patients are particularly susceptible to cardiomyopathy independent of vascular disease, and recent evidence implicates cell death as a contributing factor. Given its protective role against apoptosis, we hypothesized that dietary n-6 polyunsaturated fatty acid (PUFA) may well decrease the incidence of this mode of cardiac cell death after diabetes. Male Wistar rats were first fed a diet rich in n-6 PUFA [20% (wt/wt) sunflower oil] for 4 wk followed by streptozotocin (STZ, 55 mg/kg) to… CONTINUE READING
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