Brief Report: Methotrexate Prevents Wear Particle–Induced Inflammatory Osteolysis in Mice Via Activation of Adenosine A2A Receptor

@article{Mediero2015BriefRM,
  title={Brief Report: Methotrexate Prevents Wear Particle–Induced Inflammatory Osteolysis in Mice Via Activation of Adenosine A2A Receptor},
  author={Ar{\'a}nzazu Mediero and Miguel P{\'e}rez-Aso and Tuere Wilder and Bruce N. Cronstein},
  journal={Arthritis \& Rheumatology},
  year={2015},
  volume={67}
}
Adenosine, acting at the A2A receptor, mediates the antiinflammatory effects of methotrexate (MTX) in models of inflammation. We previously reported that A2A receptor ligation diminishes wear particle–driven osteolysis. The aim of this study was to investigate whether MTX treatment could prevent bone resorption caused by inflammatory osteolysis. 
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