Brief Definitive Report Specific Genomic Markers for the Hla-dq Subregion Discriminate between Dr4 + Insulin- Dependent Diabetes Mellitus and Dr4 + Seropositive Juvenile Rheumatoid Arthritis

@inproceedings{Nepom2003BriefDR,
  title={Brief Definitive Report Specific Genomic Markers for the Hla-dq Subregion Discriminate between Dr4 + Insulin- Dependent Diabetes Mellitus and Dr4 + Seropositive Juvenile Rheumatoid Arthritis},
  author={Barbara S. Nepom and JERRY PALMER and SE JONG KIM and John A Hansen and Susan L. Holbeck and Gerald T Nepom},
  year={2003}
}
HLA-DR4, like most o ther HLA-DR specificities, is a serologically def ined public specificity present on a n u m b er o f different haplotypes. Hapiotypes that share the DR4 specificity may differ considerably; polypeptide products o f H LA class II genes in the DR and DQ regions vary among different DR4 + cells (1-4) and restriction endonuclease f ragment length polymorphisms (RFLP) identify nucleotide variation among different DR4 + haplotypes (5). Polymorphic variations within HLA class II… CONTINUE READING