Brief Definitive Report INDUCTION OF TOLERANCE TO ONE DETERMINANT ON A SYNTHETIC PEPTIDE DOES NOT AFFECT THE RESPONSE TO A SECOND LINKED DETERMINANT Implications for the Mechanism of Neonatal Tolerance Induction

Abstract

Neonatal T lymphocyte tolerance to proteins has been extensively studied, but the underlying mechanisms are still unknown (1-3). One hypothesis is that tolerance is due to the inactivation of T cells on contact with antigen at an early stage of development. Alternatively, tolerance may be the result of the stimulation of other T cells, which actively… (More)

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