Brief Communications Effects of Proton Buffering and of Amiloride Derivatives on Reperfusion Arrhythmias in Isolated Rat Hearts


We investigated the hypothesis that an accelerated Na+O-HWi exchange on reperfusion may lead to a displacement of the 3 [Nat] [Ca2'] i/o equilibrium in favor of an arrhythmogenic rise in cytosolic [Ca2+]. Supporting evidence was obtained by subjection of isolated rat hearts to 15 minutes of low-flow (5% of control) ischemia and 2 minutes of reperfusion in… (More)


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