Brief Communication: Tamoxifen Therapy for Nonmalignant Retroperitoneal Fibrosis

@article{Bommel2006BriefCT,
  title={Brief Communication: Tamoxifen Therapy for Nonmalignant Retroperitoneal Fibrosis},
  author={E. V. van Bommel and T. R. Hendriksz and A. W. Huiskes and A. G. Zeegers},
  journal={Annals of Internal Medicine},
  year={2006},
  volume={144},
  pages={101-106}
}
Context There are few effective treatments for retroperitoneal fibrosis. Contribution Of 19 adults with nonmalignant retroperitoneal fibrosis treated with tamoxifen for variable durations of time, 15 reported substantial resolution of symptoms and 14 had computed tomography scans that showed slow regression of retroperitoneal masses. Three men reported minor losses of libido, and 1 patient developed reversible hepatitis. Caution There was no control group in this small observational study… Expand

Paper Mentions

Interventional Clinical Trial
This is a prospective study to investigate the treatment response of Tocilizumab on patients with idiopathic retroperitoneal fibrosis(IRPF). Methods: All the patients… Expand
ConditionsIdiopathic Retroperitoneal Fibrosis
InterventionDrug
Interventional Clinical Trial
Idiopathic retroperitoneal fibrosis (IRF) is a rare disease characterised by the presence of a retroperitoneal periaortic fibro-inflammatory tissue which may entrap the ureters and… Expand
ConditionsRetroperitoneal Fibrosis
InterventionDrug
Tamoxifen Monotherapy in the Treatment of Retroperitoneal Fibrosis
TLDR
Tamoxifen is an alternative in the medical treatment of RPF, especially if patients want to avoid glucocorticoids and the potential of regression of fibrosis seems to be slightly inferior and the relapse rate is higher compared to steroids, but the rate of successful DJ removals is comparable. Expand
Outcome in patients with idiopathic retroperitoneal fibrosis treated with corticosteroid or tamoxifen monotherapy
TLDR
CS are superior to TMX in treating iRPF disease, however, in patients with initial treatment success with primary treatment, recurrence rate was lower in TMX-treated patients. Expand
Long-term safety and efficacy of a tamoxifen-based treatment strategy for idiopathic retroperitoneal fibrosis.
TLDR
Tamoxifen is a safe and viable therapeutic option in the treatment of iRPF and responded satisfactorily to second-line immunosuppressive treatment. Expand
Medical management of retroperitoneal fibrosis.
TLDR
Combined prednisone and mycophenolate mofetil appears to be an effective therapeutic option for patients with retroperitoneal fibrosis. Expand
Long-term renal and patient outcome in idiopathic retroperitoneal fibrosis treated with prednisone.
TLDR
One-year treatment with prednisone is associated with a high rate of initial success, but a high recurrence rate, and despite frequent disease relapse, long-term renal and patient outcome was good. Expand
Prednisone versus tamoxifen in patients with idiopathic retroperitoneal fibrosis: an open-label randomised controlled trial
TLDR
Prednisone is more effective in prevention of relapses than is tamoxifen in patients with idiopathic retroperitoneal fibrosis, and should be considered as first-line treatment for patients with newly diagnosed idiopATHic retro Peritoneal Fibrosis. Expand
Combined Prednisone and Mycophenolate Mofetil Treatment for Retroperitoneal Fibrosis
TLDR
Combined prednisone and mycophenolate mofetil therapy is a potentially effective treatment for retroperitoneal fibrosis that warrants evaluation in randomized trials. Expand
Retroperitoneal fibrosis after chemo‐radiotherapy for cervical cancer: A case report
TLDR
The case of a 47‐year‐old woman who complained of lower abdominal pain 14 months after chemo‐radiotherapy for cervical cancer and was diagnosed with RPF caused by radiotherapy, which is doing well with no recurrence to date is reported. Expand
Treatment of idiopathic retroperitoneal fibrosis with colchicine and steroids: a case series.
TLDR
Colchicine in association with a low induction dose of steroids produced remission rates in patients with IRPF similar to those for regimens using greater steroid doses alone or in combination with immunosuppressive drugs, and may have contributed to recurrence prevention. Expand
Management of idiopathic retroperitoneal fibrosis from the urologist’s perspective
TLDR
The imaging procedures available today are unable to accurately differentiate between idiopathic and malignant RF and more clinical studies are needed in order standardize the protocol for diagnostic, treatment and follow up after medical or surgical management. Expand
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References

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Treatment of retroperitoneal fibrosis with tamoxifen: case report and review of literature.
TLDR
Tamoxifen represents an attractive and safe choice of medical treatment for retroperitonea fibrosis, particularly in the acute stages, and the duration of treatment, the effectiveness and the persistence of the results are still uncertain because few cases have been reported in the literature. Expand
Steroid therapy for idiopathic retroperitoneal fibrosis: dose and duration.
TLDR
This regimen of steroid may be used as the primary mode of treatment for the majority of patients with idiopathic retroperitoneal fibrosis with minimal complications. Expand
Retroperitoneal fibrosis: report of 12 cases and a review of the literature.
TLDR
There is now considerable evidence that RPF can be treated effectively with corticosteroids and should be considered the treatment of choice, surgery being confined to medical failures or those who do not tolerate steroids. Expand
Retroperitoneal fibrosis treated with tamoxifen.
TLDR
Tamoxifen has been shown to be effective in the treatment of desmoid tumors, and a patient with retroperitoneal fibrosis who was treated successfully with this anti-estrogen may be a useful treatment in this disease. Expand
The response of retroperitoneal fibrosis to tamoxifen.
TLDR
Tamoxifen is effective in the treatment of desmoid tumors, and it is reported its use in two patients with retroperitoneal fibrosis with excellent results. Expand
Retroperitoneal fibrosis treated with methylprednisolon pulse and disease-modifying antirheumatic drugs.
TLDR
This report describes 11 cases of RF with ureteric obstruction treated with methyl-prednisolon pulse therapy in combination with azathioprine or penicillamine following initial insertion of Ureteral stents, a principle of non-operative management of RF. Expand
[Retroperitoneal fibrosis].
TLDR
A 53-year-old man without previous significant illness developed severe backache and the marked urinary obstruction necessitated the implantation of double-J-stents, which led to idiopathic retroperitoneal fibrosis being diagnosed. Expand
Remission of Idiopathic Retroperitoneal Fibrosis after Sequential Therapy with Corticosteroids and Tamoxifen
TLDR
A case of idiopathic retroperitoneal fibrosis treated successfully with intra peritonealization of the ureters and sequential therapy with steroids and tamoxifen to minimize the side effects is presented. Expand
Tamoxifen for retroperitoneal fibrosis.
TLDR
A case of a woman with retroperitoneal fibrosis associated with aortic inflammatory aneurysm, who was successfully treated with oral tamoxifen is reported. Expand
Computed tomography in the follow-up of retroperitoneal fibrosis.
TLDR
Serial abdominal computed tomography scans have been performed in 15 patients with biopsy-proven idiopathic retroperitoneal fibrosis and all 12 patients showed a decrease in the size of the retro peritoneal mass at follow-up, although two had not been treated with steroids. Expand
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