Bridging Innate and Adaptive Immunity in African Trypanosomiasis

  title={Bridging Innate and Adaptive Immunity in African Trypanosomiasis},
  author={John Melvin Mansfield and Donna M. Paulnock and Gina M. Hedberg},
Infection of man and domestic animals with Brucei group African trypanosomes results in a fatal disease. The immunobiological events that underlie temporal host resistance and susceptibility during an infection are complex but informative, because the parasites activate and engage nearly every element of the host innate and adaptive immune system. The ability of trypanosomes to undergo extensive antigenic variation provides a means to escape adaptive immunity, but these protozoan pathogens also… CONTINUE READING