Bridges of Calcium Bicarbonate Tightly Couple Dipolar Lipid Membranes

  title={Bridges of Calcium Bicarbonate Tightly Couple Dipolar Lipid Membranes},
  author={Lea Fink and Christoph Allolio and Jehuda Feitelson and Carmen Tamburu and Daniel Harries and Uri Raviv},
  pages={10715 - 10724}
The interaction between lipid membranes and ions is associated with a range of key physiological processes. Most earlier studies have focused on the interaction of lipids with cations, while the specific effects of the anions have been largely overlooked. Owing to dissolved atmospheric carbon dioxide, bicarbonate is an important ubiquitous anion in aqueous media. In this paper, we report on the effect of bicarbonate anions on the interactions between dipolar lipid membranes in the presence of… Expand
3 Citations
Reactive Monte Carlo Simulations for Charge Regulation
We present a reactive Monte Carlo simulation method to study acid-base equilibrium that controls charge regulation in colloidal systems. The simulations use a semi-grand canonical ensemble in whichExpand
Effect of the ammonium salt anion on the structure of doxorubicin complex and PEGylated liposomal doxorubicin nanodrugs.
It was demonstrated that PLD made with ammonium-methane sulfonate exhibit a much lower Hand and Foot syndrome and strongly depend on the counteranions. Expand
Biomineralization at fluid interfaces.
The fruitful and exciting crossroad between Colloid and Interface Science with Biomineralization is exhibited, showing their improved biocompatibility and on-demand delivery features. Expand


Osmotic Stress Induced Desorption of Calcium Ions from Dipolar Lipid Membranes.
The data and modeling show that when low osmotic stress is applied to the DLPC bilayers, the membrane charge density is equivalent to that of a charged membrane containing ca. Expand
Multistep binding of divalent cations to phospholipid bilayers: a molecular dynamics study.
This study confirmed that even the binding of monovalent ions is unexpectedly slow, and it predicted a reduced self-diffusion coefficient for the lipids under the influence of sodium chloride, which was subsequently confirmed by fluorescence correlation spectroscopy. Expand
Structure and Interactions between Charged Lipid Membranes in the Presence of Multivalent Ions.
It is discovered that tightly coupled membrane lamellar phases, dominated by attractive interactions, coexisted with weakly coupled lamellars phases,dominated by repulsive interactions, which had significantly larger D values, although consistently shorter than the D values in monovalent salt solutions with similar screening lengths. Expand
The structure of ions and zwitterionic lipids regulates the charge of dipolar membranes.
This study models biologically relevant interactions between cell membranes and various ions and the manner in which the lipid structure governs those interactions and suggests that the relatively loose packing of lipids with unsaturated tails that increases the area per lipid headgroup, enabling their free rotation. Expand
Critical Conditions for Adsorption of Calcium Ions onto Dipolar Lipid Membranes.
The findings suggest that calcium adsorption to DLPC membranes requires an initial nucleation phase, and the structure of the lamellar phases formed at CaCl2 concentrations below and above the critical concentration is determined. Expand
Calcium binding and head group dipole angle in phosphatidylserine-phosphatidylcholine bilayers.
Molecular dynamics simulations of mixed, zwitterionic-anionic, asymmetric phospholipid bilayers with monovalent and divalent cations with results consistent with experimental observations point the way to further refinement and increased realism of these molecular models. Expand
Structural effects of neutral lipids on divalent cation-induced interactions of phosphatidylserine-containing bilayers.
The data indicate that neutral lipid is both dehydrated during the rapid collapse process of Ca(PS)2 formation and accommodated within this dehydrated structure, and contributes to the dehydration of neighboring neutral lipids that likely form continuous bilayers with them. Expand
Swelling of phospholipids by monovalent salt Published, JLR Papers in Press, November 2, 2005.
It is confirmed here that multilamellar vesicles swell in salt solutions, a direct indication that salt modifies the interactions between neighboring membranes, eliminating the possibility that swelling is an equilibration artifact. Expand
The adsorption of divalent cations to phosphatidylcholine bilayer membranes.
Electrophoretic mobility and 31P NMR measurements were combined to test whether the combination of the Henry, Boltzmann and Grahame equations is capable of describing the adsorption of divalentExpand
Influence of anions and cations on the dipole potential of phosphatidylcholine vesicles: a basis for the Hofmeister effect.
The results presented provide a molecular basis for the interpretation of the Hofmeister effect of lyotropic anions on ion transport proteins. Expand