Bridger: a new framework for de novo transcriptome assembly using RNA-seq data

  title={Bridger: a new framework for de novo transcriptome assembly using RNA-seq data},
  author={Zheng Chang and Guojun Li and Juntao Liu and Yu Zhang and Cody Ashby and Deli Liu and Carole L. Cramer and Xiuzhen Huang},
  booktitle={Genome Biology},
We present a new de novo transcriptome assembler, Bridger, which takes advantage of techniques employed in Cufflinks to overcome limitations of the existing de novo assemblers. When tested on dog, human, and mouse RNA-seq data, Bridger assembled more full-length reference transcripts while reporting considerably fewer candidate transcripts, hence greatly reducing false positive transcripts in comparison with the state-of-the-art assemblers. It runs substantially faster and requires much less… CONTINUE READING
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