Bridge and brick network motifs: Identifying significant building blocks from complex biological systems

@article{Huang2007BridgeAB,
  title={Bridge and brick network motifs: Identifying significant building blocks from complex biological systems},
  author={Chung-Yuan Huang and Chia-Ying Cheng and Chuen-Tsai Sun},
  journal={Artificial intelligence in medicine},
  year={2007},
  volume={41 2},
  pages={117-27}
}
OBJECTIVE A major focus in computational system biology research is defining organizing principles that govern complex biological network formation and evolution. The task is considered a major challenge because network behavior and function prediction requires the identification of functionally and statistically important motifs. Here we propose an algorithm for performing two tasks simultaneously: (a) detecting global statistical features and local connection structures in biological networks… CONTINUE READING
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