Bricks and mortar of the epidermal barrier

  title={Bricks and mortar of the epidermal barrier},
  author={Zolt{\'a}n Nemes and Peter M. Steinert},
  journal={Experimental & Molecular Medicine},
A specialized tissue type, the keratinizing epithelium, protects terrestrial mammals from water loss and noxious physical, chemical and mechanical insults. This barrier between the body and the environment is constantly maintained by reproduction of inner living epidermal keratinocytes which undergo a process of terminal differentiation and then migrate to the surface as interlocking layers of dead stratum corneum cells. These cells provide the bulwark of mechanical and chemical protection, and… CONTINUE READING