• DOI:10.3390/molecules22030475
Corpus ID: 14457400

Briarenols C–E, New Polyoxygenated Briaranes from the Octocoral Briareum excavatum

@article{Chen2017BriarenolsCN,
  title={Briarenols C–E, New Polyoxygenated Briaranes from the Octocoral Briareum excavatum},
  author={Nan-Fu Chen and Yin-Di Su and T. Hwang and Zuo-Jian Liao and K. Tsui and Z. Wen and Y. Wu and P. Sung},
  journal={Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry},
  year={2017},
  volume={22}
}

Nan-Fu Chen, Yin-Di Su, +5 authors P. Sung

Published 2017

Chemistry, Medicine

Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry

Three new polyoxygenated briarane diterpenoids, briarenols C–E (1–3), were isolated from the octocoral Briareum excavatum. The structures of briaranes 1–3 were elucidated by interpretation of spectroscopic data, and the methylenecyclohexane ring in 1 was found to exist in a twisted boat conformation. Briarenol D (2) displayed an inhibitory effect on the release of elastase by human neutrophils with an IC50 value of 4.65 μM. Briarenol E (3) was found to inhibit the protein expression of pro… CONTINUE READING

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