Brg1 promotes both tumor-suppressive and oncogenic activities at distinct stages of pancreatic cancer formation.

@article{Roy2015Brg1PB,
  title={Brg1 promotes both tumor-suppressive and oncogenic activities at distinct stages of pancreatic cancer formation.},
  author={Nilotpal Roy and Shivani Malik and Karina E. Villanueva and Atsushi Urano and Xinyuan Lu and Guido von Figura and E. Scott Seeley and David W. Dawson and Eric A. Collisson and Matthias Hebrok},
  journal={Genes & development},
  year={2015},
  volume={29 6},
  pages={658-71}
}
Pancreatic ductal adenocarcinoma (PDA) develops predominantly through pancreatic intraepithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasm (IPMN) precursor lesions. Pancreatic acinar cells are reprogrammed to a "ductal-like" state during PanIN-PDA formation. Here, we demonstrate a parallel mechanism operative in mature duct cells during which functional cells undergo "ductal retrogression" to form IPMN-PDA. We further identify critical antagonistic roles for Brahma-related… CONTINUE READING
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