Brg1 activates enhancer repertoires to establish B cell identity and modulate cell growth

Abstract

Early B cell development is orchestrated by the combined activities of the transcriptional regulators E2A, EBF1, Foxo1 and Ikaros. However, how the genome-wide binding patterns of these regulators are modulated during B lineage development remains to be determined. Here we found that in lymphoid progenitor cells, the chromatin remodeler Brg1 specified the B… (More)
DOI: 10.1038/ni.3170

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