Brevetoxin-induced autocrine excitotoxicity is associated with manifold routes of Ca2+ influx.

@article{Berman2000BrevetoxininducedAE,
  title={Brevetoxin-induced autocrine excitotoxicity is associated with manifold routes of Ca2+ influx.},
  author={Frederick W Berman and Thomas F. Murray},
  journal={Journal of neurochemistry},
  year={2000},
  volume={74 4},
  pages={1443-51}
}
Real-time alterations in intracellular Ca2+ ([Ca2+]i) were monitored in fluo-3-loaded cerebellar granule neurons (CGNs) exposed to the brevetoxin PbTx-1. [Ca2+]i was measured using a fluorescent plate reader (FLIPR), which measures simultaneously the mean intracellular Ca2+ change in a population of cultured cells in each well of a 96-well plate. PbTx-1 produced rapid and concentration-dependent increases in neuronal [Ca2+]i with a potency nearly identical to that determined previously for PbTx… CONTINUE READING