Bretylium tosylate as initial treatment for cardiopulmonary arrest: randomized comparison with placebo.

@article{Nowak1981BretyliumTA,
  title={Bretylium tosylate as initial treatment for cardiopulmonary arrest: randomized comparison with placebo.},
  author={Richard Michael Nowak and T J Bodnar and S C Dronen and G D Gentzkow and Michael C Tomlanovich},
  journal={Annals of emergency medicine},
  year={1981},
  volume={10 8},
  pages={404-7}
}
To evaluate the therapeutic effectiveness of intravenous bretylium tosylate as a first-line drug for patients in cardiopulmonary arrest, a randomized, double-blind study was conducted, comparing bretylium with a normal saline placebo. Fifty-nine patients presenting to the emergency department with cardiopulmonary arrest due mainly to ventricular fibrillation or asystole initially received either bretylium (10 mg/kg) or placebo in a rapid intravenous bolus and were then otherwise treated… CONTINUE READING

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