Brefeldin a effectively inhibits cancer stem cell-like properties and MMP-9 activity in human colorectal cancer Colo 205 cells.

@article{Tseng2013BrefeldinAE,
  title={Brefeldin a effectively inhibits cancer stem cell-like properties and MMP-9 activity in human colorectal cancer Colo 205 cells.},
  author={Chao-Neng Tseng and Chien-Fu Huang and C Cho and Hsueh-Wei Chang and Chao-Wei Huang and Chien-Chih Chiu and Yung-Fu Chang},
  journal={Molecules},
  year={2013},
  volume={18 9},
  pages={10242-53}
}
Cancer stem cells (CSCs) are a small subset of cancer cells with indefinite potential for self-renewal and the capacity to drive tumorigenesis. Brefeldin A (BFA) is an antibiotic that is known to block protein transport and induce endoplasmic reticulum (ER) stress in eukaryotic cells, but its effects on colorectal CSCs are unknown. We investigated the inhibitory effect of BFA on human colorectal cancer Colo 205 cells. We found that BFA effectively reduced the survival of suspension Colo 205… CONTINUE READING
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