Brefeldin A implicates egress from endoplasmic reticulum in class I restricted antigen presentation


MOST antigens must be processed intracellularly before they can be presented, in association with major histocompatibility complex (MHC) molecules at the cell surface, for recognition by the antigen-specific receptor of T cells1–3. This processing appears to involve cleavage of protein antigens to Smaller peptides4–7. Only certain fragments of any protein… (More)
DOI: 10.1038/339223a0


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