Brefeldin A, a cytotoxin produced by Paecilomyces sp. and Aspergillus clavatus isolated from Taxus mairei and Torreya grandis.

@article{Wang2002BrefeldinAA,
  title={Brefeldin A, a cytotoxin produced by Paecilomyces sp. and Aspergillus clavatus isolated from Taxus mairei and Torreya grandis.},
  author={Jianfeng Wang and Yaojian Huang and Mei-juan Fang and Yongjie Zhang and Zhonghui Zheng and Yufen Zhao and Wenjin Su},
  journal={FEMS immunology and medical microbiology},
  year={2002},
  volume={34 1},
  pages={
          51-7
        }
}
Paecilomyces sp. and Aspergillus clavatus, which were isolated from Taxus mairei and Torreya grandis from southeast China, produced toxic metabolites when grown in liquid culture. Nuclear magnetic resonance techniques, infrared spectrometry, electrospray ionization mass spectroscopy and X-ray analysis identified brefeldin A, a bioactive metabolite produced by a number of fungal species belonging to the genera Alternaria, Ascochyta, Penicillium, Curvularia, Cercospora and Phyllosticta. This is… CONTINUE READING

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