Breed Distribution of SOD1 Alleles Previously Associated with Canine Degenerative Myelopathy

  title={Breed Distribution of SOD1 Alleles Previously Associated with Canine Degenerative Myelopathy},
  author={Rong Zeng and J. R. Coates and G.S. Johnson and L. Hansen and Tomoyuki Awano and Ana Let{\'i}cia Kolicheski and Emma Ivansson and Michele Perloski and Kerstin Lindblad-Toh and Dp O'Brien and J Guo and M L Katz and GS Johnson},
  journal={Journal of Veterinary Internal Medicine},
  pages={515 - 521}
Background Previous reports associated 2 mutant SOD1 alleles (SOD1:c.118A and SOD1:c.52T) with degenerative myelopathy in 6 canine breeds. The distribution of these alleles in other breeds has not been reported. Objective To describe the distribution of SOD1:c.118A and SOD1:c.52T in 222 breeds. Animals DNA from 33,747 dogs was genotyped at SOD1:c.118,SOD1:c.52, or both. Spinal cord sections from 249 of these dogs were examined. Methods Retrospective analysis of 35,359 previously determined… 

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  • J. Coates, F. Wininger
  • Medicine, Biology
    The Veterinary clinics of North America. Small animal practice
  • 2010