Breed Distribution of SOD1 Alleles Previously Associated with Canine Degenerative Myelopathy

@inproceedings{Zeng2014BreedDO,
  title={Breed Distribution of SOD1 Alleles Previously Associated with Canine Degenerative Myelopathy},
  author={Rong Zeng and Jr Coates and Gc Johnson and Liz Hansen and Tomoyuki Awano and Ana Let{\'i}cia Kolicheski and Emma L. Ivansson and Michele Perloski and Kerstin Lindblad-Toh and DP O'Brien and Junying Guo and ML Katz and GS Johnson},
  booktitle={Journal of veterinary internal medicine},
  year={2014}
}
BACKGROUND Previous reports associated 2 mutant SOD1 alleles (SOD1:c.118A and SOD1:c.52T) with degenerative myelopathy in 6 canine breeds. The distribution of these alleles in other breeds has not been reported. OBJECTIVE To describe the distribution of SOD1:c.118A and SOD1:c.52T in 222 breeds. ANIMALS DNA from 33,747 dogs was genotyped at SOD1:c.118, SOD1:c.52, or both. Spinal cord sections from 249 of these dogs were examined. METHODS Retrospective analysis of 35,359 previously… CONTINUE READING
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