Breastfeeding modulates neonatal innate immune responses: a prospective birth cohort study

@article{Belderbos2012BreastfeedingMN,
  title={Breastfeeding modulates neonatal innate immune responses: a prospective birth cohort study},
  author={Mirjam E Belderbos and Michiel L. Houben and Grada M. van Bleek and Leontine Schuijff and N. van Uden and Eltje M Bloemen-Carlier and Jan L. L. Kimpen and Marinus J. C. Eijkemans and Maroeska M Rovers and Louis Bont},
  journal={Pediatric Allergy and Immunology},
  year={2012},
  volume={23}
}
To cite this article: Belderbos ME, Houben ML, van Bleek GM, Schuijff L, van Uden NOP, Bloemen‐Carlier EM, Kimpen JLL, Eijkemans MJC, Rovers M, Bont LJ. Breastfeeding modulates neonatal innate immune responses: a prospective birth cohort study. Pediatric Allergy Immunology 2012: 23: 65–74. 
Maternal milk cytokines : potential immunomodulatory role in infant Giardia infection
Article history: Article history: Received 18 December 2016 Accepted 16 February 2017 Available online 25 February 2017
Breast feeding and early life immunomodulation
To the Editor, We have read with interest the article from Belderbos et al. (1) suggesting the ability of breastfeeding to down-modulate the secretion of TNF-a and IL-10 by white blood cells in termExpand
Breastfeeding and wheeze prevalence in pre‐schoolers and pre‐adolescents: the Genesis and Healthy Growth studies
TLDR
The relation of diverse infantile feeding patterns with wheeze/asthma prevalence in two cohorts of children of different ages (preschool and preadolescent) is investigated. Expand
Early life response to infection
TLDR
The view that greater consideration should be given to understanding the set point in the regulation of homeostatic control of innate and adaptive immunity and its interplay with metabolism and the newly acquired microbiome is advanced. Expand
Plasma‐mediated immune suppression: a neonatal perspective
TLDR
How immune regulation by these factors, which are particularly abundant in neonatal plasma, may eventually be used to treat immune‐mediated diseases, such as autoimmune, allergic, and inflammatory diseases are outlined. Expand
Prenatal and early-life exposures alter expression of innate immunity genes: the PASTURE cohort study.
TLDR
Farming-related exposures, such as raw farm milk consumption, that were previously reported to decrease the risk for allergic outcomes were associated with a change in gene expression of innate immunity receptors in early life. Expand
Toll-like receptor signaling in neonatal sepsis and inflammation: a matter of orchestration and conditioning
TLDR
It is concluded that neonatal innate immunity is not generally less able to respond to TLR stimulation and better understanding of the complex interplay of pre- and postnatal conditions and maturation-dependent neonatal TLR function may provide new therapeutic approaches. Expand
Toll-like receptor signaling in neonatal sepsis and inflammation: a matter of orchestration and
TLDR
It is concluded that neonatal innate immunity is not generally less able to respond to TLR stimulation and better understanding of the complex interplay of pre- and postnatal conditions and maturation-dependent neonatal TLR function may provide new therapeutic approaches. Expand
Can breastfeeding protect against antimicrobial resistance?
TLDR
It is suggested that breastfeeding and human milk supplements deserve greater attention as potential preventive measures in the global effort to combat antimicrobial resistance, particularly in low- and middle-income settings. Expand
Black currant seed oil supplementation of mothers enhances IFN‐γ and suppresses IL‐4 production in breast milk
  • P. Linnamaa, K. Nieminen, +5 authors J. Savolainen
  • Medicine
  • Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
  • 2013
TLDR
The cytokines in breast milk of mother of newborn infants and their associations with black currant seed oil (BCSO) supplementation during pregnancy, mother's atopic status and the development of infant's atopy dermatitis are assessed. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 36 REFERENCES
Immune regulatory cytokines in the milk of lactating women from farming and urban environments
  • D. Peroni, L. Pescollderungg, +6 authors A. Boner
  • Medicine
  • Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
  • 2010
TLDR
Immune regulatory cytokines in the milk of lactating women from farming and urban environments are studied to find out if these cytokines are regulated in order to protect against infectious disease. Expand
Evaluation of the effects of probiotic supplementation from the neonatal period on innate immune development in infancy
TLDR
This data indicates that direct stimulation of the innate immune system by microbial stimulation is critical for normal immune maturation and may also be important for inhibiting allergic‐immune responses. Expand
Neonatal interleukin‐12 capacity is associated with variations in allergen‐specific immune responses in the neonatal and postnatal periods
  • S. Prescott, A. Taylor, +4 authors P. Holt
  • Medicine
  • Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 2003
TLDR
The relationships between the capacity for IL‐12 responses in the neonatal period and atopic risk (family allergy), in vitro T cell responses to allergens, and the subsequent development of allergic disease at 6 years are examined. Expand
Breastfeeding reduces the severity of respiratory syncytial virus infection among young infants: A multi‐center prospective study
Background:  The objective of this study was to evaluate the effects of breastfeeding on the severity of respiratory syncytial virus infection in early infancy.
Maternal allergy modulates cord blood hematopoietic progenitor Toll-like receptor expression and function.
BACKGROUND Little is known regarding the prenatal determinants of innate immune responses in relation to infant allergic risk. Environmental exposures, including microbial stimuli, might predisposeExpand
Neonatal innate immunity in allergy development
TLDR
Dose, site and timing of allergen exposure are likely to modulate the innate immune response, polarizing the maturing neonatal immune system towards Th1 or Th2-type responses, thereby protecting from or predisposing to asthma and allergies. Expand
Prenatal versus postnatal sensitization to environmental allergens in a high-risk birth cohort.
TLDR
Priming of T(H)2 responses associated with persistent HDM-IgE production occurs entirely postnatally, as HDM reactivity in cord blood seems nonspecific and is unrelated to subsequent development of allergen-specific T( H)2 memory or IgE. Expand
Breastfeeding reduces immune activation in primary respiratory syncytial virus infection.
TLDR
High sCD25 concentrations during the acute phase of infection, previously associated with severe RSV disease, were significantly and independently reduced in association with breastfeeding, whereas the Th1/Th3 balance was only modified in the recovery phase. Expand
Maternal smoking is associated with impaired neonatal toll-like-receptor-mediated immune responses
TLDR
It is indicated that in addition to effects on developing airways, maternal smoking also has significant immunological effects in pregnancy, which could contribute to the well recognised, subsequent increased risk of respiratory infections and asthma. Expand
Effect of Labor on Lymphocyte Subsets in Full‐Term Neonates
TLDR
Cord blood obtained at delivery from full‐term neonates, six born vaginally and six born by elective Cesarean section, was analyzed for lymphocyte subsets to determine the lymphocyte phenotype frequencies in these neonates. Expand
...
1
2
3
4
...