Breast tumor kinase BRK requires kinesin-2 subunit KAP3A in modulation of cell migration.

@article{Lukong2008BreastTK,
  title={Breast tumor kinase BRK requires kinesin-2 subunit KAP3A in modulation of cell migration.},
  author={Kiven Erique Lukong and St{\'e}phane Richard},
  journal={Cellular signalling},
  year={2008},
  volume={20 2},
  pages={
          432-42
        }
}
BReast tumor Kinase (BRK) also known as protein kinase 6 (PTK6) is a nonreceptor tyrosine kinase overexpressed in the majority of human breast tumors. Although some studies have implicated BRK in signalling, cell proliferation and migration, the precise intracellular role of BRK has not been fully elucidated. The RNA-binding protein Sam68, and adaptor proteins paxillin and STAT3 are the only BRK substrates that link BRK to signal transduction. To identify new BRK substrates, we screened high… CONTINUE READING
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