Breast milk and in utero transmission of HIV-1 select for envelope variants with unique molecular signatures

@inproceedings{Nakamura2017BreastMA,
  title={Breast milk and in utero transmission of HIV-1 select for envelope variants with unique molecular signatures},
  author={Kyle J. Nakamura and Laura M Heath and Edwin R. Sobrera and Thomas A. Wilkinson and Katherine E. A. Semrau and Chipepo Kankasa and Nicole H. Tobin and Nicholas E. Webb and Benhur Lee and Donald M. Thea and Louise Kuhn and James I. Mullins and Grace M Aldrovandi},
  booktitle={Retrovirology},
  year={2017}
}
Mother-to-child transmission of human immunodeficiency virus-type 1 (HIV-1) poses a serious health threat in developing countries, and adequate interventions are as yet unrealized. HIV-1 infection is frequently initiated by a single founder viral variant, but the factors that influence particular variant selection are poorly understood. Our analysis of 647 full-length HIV-1 subtype C and G viral envelope sequences from 22 mother–infant pairs reveals unique genotypic and phenotypic signatures… CONTINUE READING
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